Criticism is not a four-letter word: Best practices for constructive feedback in the peer review of teaching.

In recent years, peer review of teaching (PROT) has become an increasingly important tool for evaluating library instruction. Most PROT programs consist of three components: a pre-observation meeting, the observation of teaching, and a post-observation session. The post-observation feedback session can be especially challenging—for both the observer and the observed. Drawing upon literature addressing the peer review of teaching, the authors recommend a set of best practices for providing constructive criticism to fellow instruction librarians

The Power of Observation: How Librarians can Benefit from the Peer Review of Teaching Even Without a Formal PROT Program

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Evaluation of Cocoyam-Soybean Flour Blends and Sensory Properties of the Amala Dumpling

Amala, a staple food among the Yoruba people of South West Nigeria, is mostly produced from yam. Since yam is known to be mostly carbohydrate and soybean is a legume with an appreciable quantity of protein, efforts have been made to prepare amala from the blends of cocoyam and soybean flours. The protein content of the flour blends ranged from 3.73% to 13.81%. In general, there was increase in the concentration of protein with increasing level of soy flour substitution. Unlike protein, the crude fibre content of the flour blends decreased with increasing supplementation of soy flour. Increase in oil content of the flour samples, with increasing addition of soy flour, predisposes the samples to shorter shell life and off flavor because of liability to rancidity. The lowest bulk density of 0.78 g/cm3 was recorded for sample A (100% cocoyam flour) and hence none of the flour blends could be considered as a complimentary infant substitute. In general, supplementation of cocoyam flour with soy flour enhanced the concentrations of protein, ash and dietary fibre. Therefore, it is hoped that consumption of cocoyam amala supplemented with soy flour, a cheap source of plant protein, will not only create dietary diversity, it will make more protein available for the consumers and thus help in alleviating the problem of protein energy malnutrition in developing regions of the world

Peer Review of Teaching: Best Practices for a Non-Programmatic Approach

Many academic librarians who provide library instruction have never received formal training in educational theory and methods. In an effort to bridge this gap and improve the teaching skills of instruction librarians, some academic libraries have established peer review of teaching programs. Despite the recognized benefits of peer review, it may not be feasible for every library to establish such a program. In an effort to aid those who are interested in peer review, but who may not be able to participate in a formal program, the authors identify the principles of peer review that can be applied on a non-programmatic basis. Six areas of best practice are described: establishing an environment of trust, respect, and confidentiality; selecting a suitable partner for the process; communicating with a peer reviewer; focusing on specific aspects of teaching where feedback is desired; making time for the process; and preparing oneself to accept criticism

Mechanism of active targeting in solid tumors with transferrin-containing gold nanoparticles

PEGylated gold nanoparticles are decorated with various amounts of human transferrin (Tf) to give a series of Tf-targeted particles with near-constant size and electrokinetic potential. The effects of Tf content on nanoparticle tumor targeting were investigated in mice bearing s.c. Neuro2A tumors. Quantitative biodistributions of the nanoparticles 24 h after i.v. tail-vein injections show that the nanoparticle accumulations in the tumors and other organs are independent of Tf. However, the nanoparticle localizations within a particular organ are influenced by the Tf content. In tumor tissue, the content of targeting ligands significantly influences the number of nanoparticles localized within the cancer cells. In liver tissue, high Tf content leads to small amounts of the nanoparticles residing in hepatocytes, whereas most nanoparticles remain in nonparenchymal cells. These results suggest that targeted nanoparticles can provide greater intracellular delivery of therapeutic agents to the cancer cells within solid tumors than their nontargeted analogs

Associations between Cognition, Gender and Monocyte Activation among HIV Infected Individuals in Nigeria.

The potential role of gender in the occurrence of HIV-related neurocognitive impairment (NCI) and associations with markers of HIV-related immune activity has not been previously examined. In this study 149 antiretroviral-naïve seropositive subjects in Nigeria (SP, 92 women and 57 men) and 58 seronegative (SN, 38 women and 20 men) were administered neuropsychological testing that assessed 7 ability domains. From the neuropsychological test scores was calculated a global deficit score (GDS), a measure of overall NCI. Percentages of circulating monocytes and plasma HIV RNA, soluble CD163 and soluble CD14 levels were also assessed. HIV SP women were found to be younger, more educated and had higher CD4+ T cell counts and borderline higher viral load measures than SP men. On the neuropsychological testing, SP women were more impaired in speed of information processing and verbal fluency and had a higher mean GDS than SN women. Compared to SP men, SP women were also more impaired in speed of information processing and verbal fluency as well as on tests of learning and memory. Numbers of circulating monocytes and plasma sCD14 and sCD163 levels were significantly higher for all SP versus all SN individuals and were also higher for SP women and for SP men versus their SN counterparts. Among SP women, soluble CD14 levels were slightly higher than for SP men, and SP women had higher viral load measurements and were more likely to have detectable virus than SP men. Higher sCD14 levels among SP women correlated with more severe global impairment, and higher viral load measurements correlated with higher monocyte numbers and sCD14 and sCD14 levels, associations that were not observed for SP men. These studies suggest that the risk of developing NCI differ for HIV infected women and men in Nigeria and, for women, may be linked to effects from higher plasma levels of HIV driving activation of circulating monocytes

By and for Us: The Development of a Program for Peer Review of Teaching by and for Pre-Tenure Librarians

Seven pre-tenure librarians at the University Library at Indiana University-Purdue University Indianapolis (IUPUI) created a peer review of teaching (PROT) group. This article provides an overview of the library literature on PROT and identifies the commonalities and variations found in PROT programs. The development, implementation, and benefits of the PROT program at IUPUI are discussed as well as outcomes pertaining to benefits for the observed, the observer, and for the PROT group as a whole. The authors also found that the implementation of a PROT program can enhance the sense of community among colleagues

Effect of Oral Administration of Honey on Arginase Activity of Rats Exposed to Smoke

In this paper, we report the effect of oral administration of 125 mg/kg honey on the liver and kidney arginase activity of rats exposed to smoke from hydrocarbon-fueled lantern. Eighteen Wistar albino rats (weighing 150-200 g) were randomly assigned into three groups of 6 rats each. Group one served as the control (CTR) that was not exposed to smoke while Group two and three were exposed to smoke alone (SMW) and smoke with honey (SMH) respectively for 12 weeks. Results showed that the inhalation of smoke by the rats for 12 weeks significantly (p<0.05) reduced the total weight gain of experimental rats. The integrity of the liver and kidney were compromised in the SMW group as compared to the control and the SMH rats. There was a significant increase in arginase activity of SMW rats as compared to the control rats; Liver (0.71 ± 0.04 μmol/ml/min), Kidney (0.50 ± 1.07 μmol/ml/min). In addition, there was a significant reduction of arginase activity in the SMH rats as compared to the SMW rat; Liver (0.50 ± 0.06 μmol/ml/min), kidney (0.38 ± 0.60 μmol/ml/min). Our findings suggest that honey has a protective effect on liver and kidney in animals exposed to smoke.Keywords: Smoke, inhalation, honey, arginase, liver, kidne

Principal component and stepwise discriminant analysis of the morphometric traits of three dual-purpose breeds of chicken

Using the principal component procedure of SAS, 10 variables; body weight (BW), body length (BL), breast girth (BG), shank length (SL), thigh length (TL), comb length (CL), comb height (CH), wing length (WL), wattle length (WAL) and wattle thickness (WT) obtained from three dual-purpose chicken breeds (Shika, Kuroiler, and Sasso), variables were separated. Similarly, stepwise discriminant analsis procedure of the SAS software was employed to evaluate variables that contribute to the overall differences in breeds. Results showed three principal components (PC1, PC2 and PC3) were extracted for all the breeds and pooled data. 45.60% of total variance was accounted for by PC1, 28.17% by PC2 and 16.22% by PC3. The principal components partitioning of total variance were 50.80, 15.10 and 9.70%, 50.82, 19.90 and 14.90%, and 48.63, 14.00 and 12.67% for Shika, Kuroiler, and Sasso breeds respectively, with different factor loadings. Communalities ranged from 0.43-0.97, 0.45-0.83, 0.45-0.88 and 0.45-0.90, indicating that a good amount of variance was accounted for. Stepwise discriminant analysis indicated that seven morphometric traits, TL, SL, WAL, WL, CL, CH and BL, contributed significantly (P<0.001) to the separation of the birds into breeds. TL and SL, however, indicated higher discriminating power compared to others. The principal component analysis allowed for better understanding of the complex correlations among traits and reduced the number of traits along with high communalities, using only PC1, PC2 and PC3the first three PCs, without loss of information. Summary of stepwise discriminant analysis shows that lengthwise measures of long bones of the body of chickens, such as thigh and shank, are viable metrics for phenotypic differentiation of birds in the studied population.Keywords: Principal Component, Stepwise discriminant Analysis, Morphometric traits, chicken

Pharmacokinetics and tumor dynamics of the nanoparticle IT-101 from PET imaging and tumor histological measurements

IT-101, a cyclodextrin polymer-based nanoparticle containing camptothecin, is in clinical development for the treatment of cancer. Multiorgan pharmacokinetics and accumulation in tumor tissue of IT-101 is investigated by using PET. IT-101 is modified through the attachment of a 1,4,7,10-tetraazacyclododecane-1,4,7-Tris-acetic acid ligand to bind ^(64)Cu^(2+). This modification does not affect the particle size and minimally affects the surface charge of the resulting nanoparticles. PET data from ^(64)Cu-labeled IT-101 are used to quantify the in vivo biodistribution in mice bearing Neuro2A s.c. tumors. The ^(64)Cu-labeled IT-101 displays a biphasic plasma elimination. Approximately 8% of the injected dose is rapidly cleared as a low-molecular-weight fraction through the kidneys. The remaining material circulates in plasma with a terminal half-life of 13.3 h. Steadily increasing concentrations, up to 11% injected dose per cm^3, are observed in the tumor over 24 h, higher than any other tissue at that time. A 3-compartment model is used to determine vascular permeability and nanoparticle retention in tumors, and is able to accurately represent the experimental data. The calculated tumor vascular permeability indicates that the majority of nanoparticles stay intact in circulation and do not disassemble into individual polymer strands. A key assumption to modeling the tumor dynamics is that there is a “sink” for the nanoparticles within the tumor. Histological measurements using confocal microscopy show that IT-101 localizes within tumor cells and provides the sink in the tumor for the nanoparticles